Transforming Genetic Medicine & Genome Engineering with AI
Genetic Medicine
Develop genetic medicines—safer, smarter, faster—for patients
Vector & Payload Design
FORMsightAI optimizes AAV vector genomes and large/complex payloads, improving integrity, reducing truncations, and enabling tunable expression.
AI-Powered Accuracy
AI-augmented CDS optimization and rational design enhance manufacturability, lower safety risks, and reduce CpG-driven immunogenicity.
Maximizing Efficacy
Expression tuning and codon optimization improve CAR-T persistence and potency, enabling safer and more effective therapies.
Scalable Manufacturing
Demonstrated up to 5x improvements in genome integrity and 4.4x yield gains, directly lowering COGS and supporting efficient clinical translation.
Pipeline
Transforming the genetic medicine pipeline from concept to clinic with AI‑driven design and analysis
Genome Engineering
The company Colossal Biosciences trusts to advance its genome engineering programs
Next-Gen Editing Tools
Leverage breakthroughs in CRISPR and emerging genome engineering technologies to design and optimize precise genetic modifications in any genome.
AI-Powered Analysis
Combine AI-driven insights with expert biological interpretation to identify and validate key genotype-to-phenotype relationships to engineer desired traits.
Accelerate Validation
Validation analysis using amplicon or whole-genome sequencing to measure on-target efficiency and predict impactful off-target effects.
Applications
Genome Integrity Analysis
A clear, structured approach for characterizing genetic medicine
Drug Product Insights
Gain a clear view of what’s encapsidated— distribution of full vs. partial genomes and contaminated species.
Design Recommendations
Assess feasibility and computational rational design to select top-ranked vectors optimized for manufacturability.
Codon Optimization
An innovative AI technology for reaching effective genetic sequences
Define Program Objectives
Clarify biological goals for optimization, such as boosting protein expression, enhancing manufacturability, and improving safety.
Balancing Tradeoffs
Our model aligns with your goals, optimizing across multiple objectives while managing tradeoffs like increasing expression vs. minimizing truncations.
Optimization & Insights
Leverage Form Bio’s proprietary FORMsightAI model to optimize designs and identify codon substitutions that drive desirable outcomes.
Genome Assembly
Accurate reconstruction of genomes to drive discovery in genetics and biology
Genome Reconstruction
Piece together DNA fragments into accurate, contiguous sequences.
Downstream Insights
High quality assemblies that support variant detection, functional annotation, and comparative genomics.
Form Bio, the first spinout from Colossal Biosciences (2022), expands foundational multi-species genome engineering technology into human genetic medicines.
We are AI and software engineers, bioinformaticians, molecular and cellular biologists, and drug developers dedicated to accelerating genetic medicine and unlocking breakthroughs that transform health and improve lives.
Leadership Team
Michelle Chen, PhD
Doug Daniels
Joe Nipko, PhD
Amicia Elliott, PhD
Dan Shiffman
Angela Anderson
Christina Capehart
Let’s Unlock the Next Breakthrough Together
