How AI Supports the Design of More Wffwctive and Manufacturable Gene Therapy Constucts - Cover Image
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Biological Validation Studies

AI Models Predict & Optimize Vector Design Outcomes

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Best Practices Guide

Advancing AAV Gene Therapy Development with In Silico Tools

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Form Bio provides a new computational approach to therapeutic design, significantly reducing time and cost.

Key steps in the drug development process where our programs help you accelerate:

Drug Candidate Design

Form enables exploration of multiple vector designs through computationally-aided rational design. Our in silico tools provide assessments of vector genomic identity, immunogenicity, and manufacturability to optimize and de-risk gene therapy vector sequences.

Test Manufacturing

Form helps ensure you can produce an efficacious, safe drug with high enough yield, and fully characterized.

IND Enabling Studies

Form makes it easier to get critical toxicity and safety answers and to be prepared with every bit of data you’ll need for IND submission.

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Featured
Program Elements

Drug Substance Characterization

Detailed analysis of the manufactured drug product, including proportion of full AAV viral genomes to non-therapeutic encapsidated species.

Multi-Candidate Comparison

Compare the safety, yield and expression of multiple AAV constructs with different vector design elements.

Immunotoxicity Analysis

Analyze the potential risks associated with CpG islands and other viral genomic patterns.

AI-powered Candidate Optimization

Leverage large language models and deep learning to rapidly analyze billions of possible versions of a therapeutic construct.

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Scientific Case Studies

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Our Technology

A comprehensive tech suite built to enable accelerated cell and gene therapy development and computational biology at scale.

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Awards

GHP Biotechnology Awards logo
Best Computational Biology
 R&D Company 2023
Form Bio Platform
The Medicine Maker logo
The Innovation Awards
 2023
FORMsightAI
Cell & Gene Therapy
Pharma Manufacturing logo
Pharma Innovation Awards 
2023
FORMsightAI
Cell & Gene Therapy

Featured technology partners

Exclusively recommended multiomics platform for HCLS and academic segments (Google Cloud Premier Partner)

Reference platform integration for Parabricks accelerated genome sequencing

Exclusively recommended bioinformatics solution for gene therapy segment

Exclusive partner in accelerating gene therapy design & development.

Trusted by industry leaders

Trusted by Top Scientists and Organizations

Jenny Marlowe, PhD
Jenny Marlowe, PhD
Chief scientific Officer, solid biosciences

"As a Form Bio customer, we are thrilled with the uniquely valuable AI-driven insights they've contributed to our research and development efforts. By working closely with this world class team and cutting edge technology, we can clearly see that applying innovative AI solutions to pre-clinical cell and gene therapy development offers exciting potential for CGT companies' economics, market timing and ability to impact human health."

George Church, PhD
George Church, PhD
Professor, harvard medical school & MIT; Director of synthetic biology, the wyss institute

"Computer-aided design, fabrication, testing analyses and machine learning are key to the future of bioengineering in general and specifically restoration of endangered and extinct genetic diversity for keystone species in vital ecosystems. Form Bio is the software critical to pave the way."

Eriona Hysolli, PhD
Eriona Hysolli, PhD
Head of biological sciences, Colossal biosciences

"Form Bio helps Colossal's biology teams save time and maximize our research in ways we didn’t realize were possible. Having access to an incredibly easy-to-use interface coupled with Form’s deep bench of bioinformatics and data science expertise is core to our workflows and how we fulfill our ambitious research objectives."