Form Bio for Cell and Gene Therapy

Form was inspired by both the importance and the difficulty involved with developing new therapies and making them ready for market. Biotech company performance and success are predicated on finding the right potential therapies quickly, validating them quickly and moving them through trial and regulatory steps quickly. Indeed, time is money. But more than that, it’s discovery.

Cell and gene therapy companies are well known for attracting some of the most ambitious and accomplished minds in life science. But the computational requirements needed to reach the next breakthrough are severely limited by patchworks of difficult-to-manage custom code, siloed application and infrastructure components and antiquated processes. At Form, we understand these problems because we’ve developed our technology through months of close collaboration and consultation with leading thinkers in both science and technology.

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Benefits for Cell and Gene Therapy Companies

When you rely on Form for your bioinformatics function, you’re increasing both the potential and the speed of your research and development efforts. Here are just a few of the benefits you can expect to enjoy:

Significant reduction in resource specialization and utilization necessary to conduct research
Improved time to delivery for your discovery and trials processes
Enhanced collaboration between your teams, partners and regulatory bodies
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What Cell and Gene Therapy Companies Can Do With Form

Here are just a few ways we help:

Upload and organize your data with ease and compliance

Pick from our growing list of common workflows and run them with a click

Visualize your workflow results in presentation-quality charts and graphs

Easily invite and collaborate with colleagues and stakeholders

Example Use Cases

Form opens up virtually unlimited opportunities for you to take on consequential research that might be extraordinarily challenging otherwise. But here are just a few examples:

Run multiple types of expression analysis with a click, to determine gene abundance, splice variants, analyze differentials, count transcripts and more

Find publicly available experimentally-derived and predicted structures, determine protein domains, predict protein function and predict 3D-structures using a Protein Accession (Uniprot, Refseq, Ensembl)

Identify single-nucleotide variants, indels and structural variants in a genomics resequencing project compared to a reference genome

Execute CRISPR base editing and knockout functions

Solution Spotlight

FORMsightAI

The Cell and Gene Therapy Design Upgrade for the AI Era

Example improvements on a publicly traded gene therapy company’s AAV construct.

UP TO
70%
DECREASE IN TRUNCATIONS
UP TO
18%
INCREASE IN FULL READS

Why It Matters

Reduce Manufacturing Costs

by avoiding costly bioreactor runs on suboptimal construct designs

Shorten Time-to-Market

by minimizing design inefficiencies that prolong manufacturing trial-and-error

Enhance Safety

by predicting and optimizing capsid fill proportion with therapeutic drug product to streamline production scaling

Extend IP Protection

by filing fresh patents on optimized construct derivatives generated with FORMsightAI

Learn More
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Solution Spotlight

Candidate Validation

Improve gene therapy manufacturability.

Sitting atop the Form platform, our Candidate Validation solution optimizes constructs—helping potentially breakthrough therapies get to the production stage with less trial and error.

Learn more

Why It Matters

Reduce Time to Market

Get novel therapies to market faster by avoiding the holdups that come with CpG islands,  secondary structure truncation and suboptimal codon usage. 

Increase Manufacturing Efficiencies

Optimize constructs for manufacturing viability, reducing the likelihood of therapy candidates that fail in production.

Reduce R&D Overspend

Save days, weeks or months of capital burn by accelerating the manufacturing path to revenue.

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Alex Smit
Founder of Stic

As a Form Bio customer, we are thrilled with the uniquely valuable AI-driven insights they’ve contributed to our research and development efforts. By working closely with this world class team and cutting edge technology, we can clearly see that applying innovative AI solutions to pre-clinical cell and gene therapy development offers exciting potential for CGT companies’ economics, market timing and ability to impact human health.

Jenny Marlowe, PhD
Chief Scientific Officer, Solid Biosciences

Computer-aided design, fabrication, testing analyses and machine learning are key to the future of bioengineering in general and specifically restoration of endangered and extinct genetic diversity for keystone species in vital ecosystems. Form Bio is the software critical to pave the way.

George Church, PhD
Professor, Harvard Medical School and MIT; Director of Synthetic Biology, The Wyss Institute

Form Bio helps Colossal's biology teams save time and maximize our research in ways we didn’t realize were possible. Having access to an incredibly easy-to-use interface coupled with Form’s deep bench of bioinformatics and data science expertise is core to our workflows and how we fulfill our ambitious research objectives.

Eriona Hysolli, PhD
Head of Biological Sciences, Colossal Biosciences

"Form Bio’s platform and experienced team are playing an indispensable role in our conservation and de-extinction research initiatives. The software’s ease-of-use and breadth of capabilities empower scientists to get more computational work done with less effort and in less time, making it a critical part of how we reach our discoveries."

Andrew Pask, PhD
Professor of Biosciences, University of Melbourne

Our collaboration with Form Bio is enabling our group to build more replicable workflows that allow us to perform routine analysis with greatly reduced analyst time—addressing a critical bottleneck in the scientific enterprise.

Vagheesh Narasimhan, PhD
Assistant Professor Department of Integrative Biology, Department of Statistics and Data Sciences, The University of Texas at Austin

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