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Industry updates, best practices and expert perspectives on computational life sciences.

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2024-07-25
Case Studies

AI/ML Optimization Reduces AAV Discovery Timeline from Years to Days

AI/ML optimization can reduce AAV discovery timelines from years to days, identifying an optimal vector design quickly and resulting in 91% full capsids.

2024-07-25
Case Studies

Optimization of the CDS Using an AI/ML Model Outperforms an Open-Source Codon Optimization Tool by Improving Enzymatic Activity by 20%

AI/ML optimization of the coding sequence (CDS) can outperform open-source codon optimization tools by increasing mRNA expression by 24% and increasing enzymatic activity by 20%.

2024-07-25
Case Studies

Reducing the Risk of Immunogenicity Using an AI/ML Model

AI/ML models can reduce the immunogenicity risk of %CpG islands through sequence optimization, while maintaining a consistent %GC content.

2024-07-25
Case Studies

AI/ML Optimization of Coding Sequences Reduces Genome Truncations in AAV Vectors

AI/ML optimization of the coding sequence (CDS) of a gene-of-interest (GOI) can de-risk AAV manufacturing by reducing partially filled AAV capsids.

2024-07-23
Case Studies

AI/ML is Able to Reliably and Reproducibly predict AAV Genome Truncation

AI simulation can reliably and reproducibly predict AAV genome truncation to help increase production lot yield and lower manufacturing costs.

2024-07-23
Case Studies

Improving AAV Manufacturability with AI/ML Simulation to Reduce Genome Truncations

Improve AAV manufacturability with AI/ML in silico techniques to identify the best performing vector design for lead candidates.

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